The purpose of this study was to examine the relationship between quality of work life and job burnout with happiness among physical education teachers in Isfahan Province. The research method was descriptive and correlational, conducted through a survey approach. The sample consisted of 325 physical education teachers from Isfahan, selected using stratified random sampling. Data were collected using three standardized questionnaires measuring quality of work life, job burnout, and happiness, and were analyzed using Pearson correlation coefficients and multiple regression analysis. The results indicated a significant relationship between social integration (a component of quality of work life) and job burnout. All dimensions of quality of work life were positively associated with happiness, while components of job burnout (emotional exhaustion, depersonalization, and reduced personal accomplishment) were significantly related to lower levels of happiness. Overall, quality of work life and happiness were at moderate levels, while job burnout was found to be high. The Department of Education should prioritize teacher participation in decision-making, ensure adequate resources, and create a balance in workload to reduce burnout and promote psychological well-being. This approach enhances organizational effectiveness and ultimately improves the quality of education, benefiting students, teachers, and society as a whole.